Prosecution lawyer Christina Slavik says Diddy caused his girlfriends and sex workers to cross state lines, and transported drugs across state lines too.
She describes Diddy as "the through line" in his enterprise, a constant as its leader as other members changed over time.
To try to prove the racketeering charge against Diddy, she says the law only requires the jury to find Diddy and another member of his enterprise committed two acts together.
She says those acts can be any of a long list, including drug distribution, kidnappings, arson and bribery.
Going into detail, she talks about hard drugs, which she says Diddy "fed to Cassie and Jane" to keep them "energised for freak offs". She says Diddy's staff - including his security team and assistants - "helped keep the drug supply high".
Some of the drugs she lists are Methamphetamine found in a Gucci pouch, Ketamine, Oxycodone which is the active ingredient in Percocet, Xanax, MDMA, GHB and mushrooms.
She says the quantity of drugs are not relevant, adding "giving drugs to someone is distribution, period".
'Constant supply'
Slavik says: "The defendant and his staff were all involved in buying and distributing drugs."
She describes the drugs as being an essential part of "freak offs", saying Diddy needed a constant supply to give to Cassie and Jane.
She also says Diddy introduced Jane to drugs and supplied her at all but one hotel night, adding that when he ran out, he had assistants or security drop off more.
She says he also made his assistant Mia do drugs, "even if she didn't want to".