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If you're just joining us, here's the story at a glance:

• The US joined Israel's conflict with Iran last night by bombing nuclear facilities at Fordow, Natanz and Isfahan;
• Donald Trump said the strikes were a "spectacular military success" and warned Iran further attacks would follow if it didn't now move towards peace;
• The UN's nuclear watchdog said it was unclear what damage had been done at Fordow, but the Natanz site was now "completely destroyed" and Isfahan suffered "very significant damage";
• Iran has branded the attacks "outrageous" and "criminal",  while its parliament has reportedly suggested closing the Strait of Hormuz in response;
• Israel has continued its strikes in Iran following the US attacks, targeting dozens of sites across the country.

Before and after satellite images of Iran's Isfahan and Natanz nuclear sites show the damage after US strikes.

Earlier, the head of the UN's nuclear watchdog said the Natanz facility had been "completely destroyed", while its underground halls "suffered a lot" (see 16.15 post).

Israeli strikes in the last two weeks had already damaged Iran's largest uranium enrichment centre there.

As you can see below, US strikes have now completely reshaped the terrain at Natanz, leaving a giant crater over the site's underground facility.

IAEA chief Rafael Grossi also said the Isfahan site had suffered "very significant damage".

General Dan Caine, chairman of the US joint chiefs of staff, said a US submarine launched more than two dozen Tomahawk cruise missiles at the Isfahan site.

The images below show the damage at the site today, with blackened scorch marks left in place where buildings stood yesterday.

To see before and after comparisons of the third site struck by US bombers - Fordow - see our 14.10 post.

Donald Trump has taken to Truth Social this evening to proclaim his Republican Party is united in a way "never seen before".

The US president has received plenty of support from within his own party following his decision to strike Iran's nuclear facilities.

But there has also been at least two GOP politicians suggesting it was unconstitutional for him to bomb Iran without approval from Congress.

Ohio representative Warren Davidson said it was "hard to conceive a rationale" that the strikes were constitutional, while Kentucky representative Thomas Massie made similar comments.

Some Democrats have called for Trump to be impeached over the unapproved military action.

The Israeli military says it's struck storage facilities deep into Iran containing its long-range Khorramshahr missiles.

The air force said the attack was launched "in broad daylight" and was the "furthest target we've struck to date" in Iran.

It said the storage facilities were located in the Yazd area of central Iran.

"We destroyed Khorramshahr missiles before they were launched at Israel and struck tunnels used to store the missiles," the update says.

The head of the UN's nuclear watchdog says he doesn't know the extent of damage at Iran's Fordow nuclear facility after US strikes.

"There are clear indications of impacts," International Atomic Energy Agency chief Rafael Grossi tells CNN, "but as for the assessment for the degree of damage underground, on this we cannot pronounce ourselves."

"No one could tell you how much it has been damaged," he says, adding that because of observed changes in the shape of the sites, "one cannot exclude that there is significant damage there."

Grossi says that the Natanz facility has been "completely destroyed," while its underground halls "suffered a lot" because of cuts to electricity as the result of Israeli attacks.

The Isfahan site has also suffered "very significant damage," he adds.

Grossi will convene an emergency meeting between the IAEA's governors tomorrow "in light of the urgent situation in Iran".

Pope Leo has joined the calls for diplomacy to return to the Middle East following another night of conflict in the region.

The pontiff said news of the overnight strikes in Iran was "alarming", calling on every member of the international community to condemn the violence.

"There are no 'distant' conflicts when human dignity is at stake," he said on X.

By Dominic Waghorn, international affairs editor

Donald Trump has upped the ante by choosing to bomb Iran's nuclear facilities, so what happens next, and how bad could things get?

The US president has given the Iranians a choice: negotiate or face devastating escalation.

The next move is down to Ayatollah Ali Khamenei, Iran's supreme leader. 

He has spent his entire life trying to roll back American power and influence in the region. Expecting him to negotiate with the US now - with B-2 bombers held to his head - is a tall order.  More likely, he will order some kind of retaliation, at least for now

He will want to deter Trump from launching more attacks and may calculate that killing Americans is the best way of doing so.  

The ayatollah knows it could drive a wedge between Trump and his MAGA supporters, who say America is getting drawn into yet another Middle Eastern war, risking US lives. 

There are plenty of US targets for Iran to aim at, with bases throughout the Middle East - Qatar, Kuwait, Iraq and Saudi Arabia. The Iranians could attack them directly with drones and missiles, or use proxies in the region - Iran-backed militias in Iraq or the Houthis based in Yemen.

Iran could threaten shipping and the oil industry in the Persian Gulf.  If the Gulf becomes a war zone, expect a big hit to the global economy and the price of oil to rocket.

But all that would invite massive retaliation from the US.  The Trump administration has spelled that out in no uncertain terms.  

America has sent an awesome amount of firepower to the region: three aircraft carrier groups bristling with fighter jets and submarines loaded with cruise missiles.

So the Iranians may instead go for the kind of asymmetric warfare they excel at. The UK could be in the firing line too.  We could see Iranian terrorist attacks here in Britain.

One way or another, this is almost certain to escalate, but could it widen and draw other countries into the conflict?

Russia and Iran have a strategic partnership agreement but it doesn't require Russia to come to its support.

Iran is also China's closest ally in the Middle East, but Beijing is also likely to sit this one out and watch from the sidelines.

Wars have unintended consequences but there are strong reasons for other powers to avoid becoming involved in this one.

Looking further ahead, there are two competing priorities to watch:

For Iran's leadership, it is all about survival.  To absorb the blows and live to fight another day, and eventually build the bomb if it can, to stop this ever happening to them again.

And Israel is equally determined that will not happen.

Watch below: Netanyahu praises Trump after US strikes

One method would be regime change in Iran, but its leadership is proving resilient so far despite the mounting challenges it faces.

Instead, it faces a long period of managing the threat posed by Iran. It will need to monitor the Iranians, watching for signs they are developing their missile programme, meddling in the region or reviving their nuclear project and then cutting them down to size when necessary. 

That could mean years more of military action and could be hugely costly for Israel and its backers, the US taxpayer.

In summary, Iran's leadership is in a very tight spot and is likely to lash out.

But the future will not be a walk in the park for Israel either - and there are big risks for America, too.

Sky News understands that the UK foreign secretary, David Lammy, has had a phone call with Iran's foreign minister, Abbas Araghchi.

We're told the foreign secretary emphasised that the UK was not involved in the US strikes on Iran's nuclear facilities overnight, and pushed Tehran to get back to the negotiating table.

According to Tehran's readout, Aragchi "strongly condemned the aggressive act of the United States and considered it a gross violation of international law".

They also claimed Lammy expressed "regret" over the US strikes. He also "rejected any role or cooperation of his country and called for the continuation of diplomacy".

Sky News understands that the UK side strongly disputes that characterisation of Lammy's words about the US strike.

We have not yet had a readout from the UK side, but we will bring it to you as soon as we have it.

France's Emmanuel Macron has called on Iran to show "the utmost restraint" following US strikes on the country's nuclear facilities.

Posting on X, the French president said he had spoken with Iran鈥檚 president, Masoud Pezeshkian, after the strikes, calling for a return to diplomacy and for Tehran to commit to renouncing nuclear weapons.

"There is no alternative: this is the only path to peace and security for all."

Macron also called for the release of two French citizens, Cecile Kohler and Jacques Paris, being held on spying charges in Iran since May 2022.

The IDF has just announced details of its own strikes in Iran today in the wake of last night's US strikes on nuclear facilities.

The military says its air force "attacked missile sites and unmanned aerial vehicles in Isfahan, Bushehr, Ahvaz and for the first time in the Yazd area".

Around 30 fighter jets attacked "dozens of military targets" in the central and southwestern cities using over 60 munitions, the IDF says.

Targets included the strategic missile headquarters in the Yazd region, which is where some long-range missiles were being stored, and where the air force says around 60 missiles were launched towards Israel.

Missile launches and military sites, as well as a drone headquarters and a storage warehouse, were struck.

The IDF added: "During the attacks, an air force aircraft identified soldiers in the Iranian military forces from fifty missile launchers and eliminated them immediately afterwards.

"The IDF will continue to reach every region and attack from Iranian soil in order to remove a threat to the State of Israel."